Tissue protective potential of Clitoria ternatea leaf extract against aluminum induced damage in albino rat

Aluminum is present in several manufactured foods and medicines and also used in water purification. Therefore, the present experiment was undertaken to determine the effect of Clitoria ternatea (CT) in modulating the aluminum maltolate (AlM) induced toxicity in liver and kidney of rats. Twenty-four rats were equally assigned into control (CON), AlM treated (AlM), CT administered (CT) and combination of AlM+CT treated groups. Both AlM and CT were orally administered for one month. We found AlM administration significantly (P<0.05) increased the liver and kidney marker enzymes, alkaline phosphatase(ALP), alanine amino transferase(AAT) and aspartate amino transferase (AST). However co-administration of CT significantly (P<0.05) decreases these marker enzyme activities against AlM-induced reduction. Furthermore, evidences from light microscopic images clearly demonstrating that AlM-induced histological alterations in liver congestion and necrotic changes at central vein and kidney tissue showing the degenerative changes in bowman's capsule and glomeruli. Moreover, simultaneous administration of CT with AlM significantly modulated the structural alteration and toxic effects of AlM.