Chalcones are a class of natural open chain flavonoids that are linked by a three carbon spacer between two aromatic rings. Chalcones and their heterocyclic analogues enjoy a range of biological activities such as antimicrobial, antioxidant, cytotoxic, anticancer, antiprotozoal, antihistaminic, antiulcer and anti-inflammatory activities which makes these compounds as a special attraction for investigation. Additionally the bielectrophilic, ketovinyl chain between the two rings is highly reactive and acts as an important chemical synthon for constructing different five, six and seven member heterocyclic scaffolds containing different hetero atoms like nitrogen, oxygen and sulfur atoms by abridgment with a variety of binucleophilic reagents. This review highlights on the chemical and biological potentials of chalcones.
Flavonoids, Chalcone, Biological Activities, Chemical Synthon
