International Journal of Research in Engineering and Applied Sciences
  • Year: 2016
  • Volume: 6
  • Issue: 8

Eco-friendly synthesis: A greener route preparation of new 1, 5-benzodiazepines and its antimicrobial activity.

  • Author:
  • Santosh S. Chobe1,, Bapu S. Jagdale1, Resham Bhalla2
  • Total Page Count: 8
  • Page Number: 26 to 33

1Organic Research Laboratory, P.G. Department of Chemistry. L V H Arts, Science and commerce College, Nashik (MS), India

2P.G. Department of Zoology, L V H Arts, Science and commerce College, Nashik

*Corresponding author: dr.resham.bhalla@gmail.com

Online published on 8 May, 2017.

Abstract

A simple, efficient, single step and environmentally benign synthesis of a new series of pyrazole containing 1 5-benzodiazepines was described here by the condensation of pyrazolone with o-phenylenediamine usingg piperidine in polyethylene glycol (PEG-400) as a reaction solvent. Thee advantages of this protocol are mild reaction condition, easy work-up, excellent yield, and avoidance of volatile organic solvent. Furthermore, these newly synthesized compounds were analyzed by spectrum and screened fortheir antimicrobial activity

Keywords

o-Phenylenediamine, PEG-400, 1,5-Benzodiazepines, Antimicrobial activity