Product quality management during production of tablet's

Tablet design and post-formulation quality monitoring requires quantitative evaluations and assessments of tablet's chemical, physical and bioavailability properties. The present work reports the comparative study and quality evaluation of tablets formulated by pharmaceutical company. Niacinamide, ferrous fumerate, paracetamol in combination with ibuprofen, nimesulide and ciprofloxacin of ‘X ’company, were collected for quality analysis and evaluation. The tablets were subjected to various post-production tests such as hardness, friability and dissolution rate following standard Indian pharmacopeia procedures. With the experimental observations recorded, various plots have been made to correlate the test parameters. From the analysis of the results, it was observed that there was no much variation in the dissolution rates but there was a considerable variation in the pattern of hardness and friability of tablets of the company because of change in recipients and other drugs. From the analysis, it was observed that the quality of ‘X ’company formulations have good agreement with the literature and can be concluded to be more reliable.

To study the various essential parameters for Product quality management and Quality maintenance with respect to dosage forms like Tablets.