Genotoxicity and Histopathological changes due to toxic effect of cadmium in Albino mice

Heavy metal toxicity is great life threatening problem for every organism including human. Heavy metal becomes toxic when they are not metabolized by the body and accumulate in soft tissue. Cadmium is a heavy metal that causes several diseases in human and has been classified as human carcinogen. Cadmium not only effect human but also other mammals. it effect the soft tissue of lung, kidney, liver, testis and also it effect in genomic level. The present study aimed to investigate that toxicological effect of heavy metal Cd (cadmium)on mammalian system(Albino mice). Histopathological changes in tissue of mice as well as chromosomal aberration and change in protein have been noticed by inducing the Cd. For this purpose mice were treated as different concentration of Cd for 90 days. Tissue were collected from both control and treated animals and studied mice exposed to Cd showed Histopathological changes in the liver, kidney, lungs and testicular tissue as well as chromosomal abnormality such as break, ring, centromeric separation were observed.