Formulation and Evaluation of Aspirin Nanoemulsion

Nanoemulsion can be defined as the emulsions with mean droplet diameter ranging from 20-500nm used as targeted drug delivery carrier in pharmaceutical products. The present objective is to formulate and evaluate the nanoemulsion of Aspirin. The first part of the work is considered to formulate Aspirin Nanoemulsion to overcome poor solubility. It is composed of Aspirin drug, Acetone as solvent, Arachis oil as oil phase, Tween 80 as surfactant, Polyethylene Glycol 400 as Co-Surfactant and Water. Various formulations of Oil in Water Nanoemulsions were prepared by varying the Smix ratios and formulating at constant temperature. Nanoemulsions were evaluated for various parameters and its compatibility studies were made. The obtained nanoemulsion has a particle size of about 111nm. FTIR data indicate the compatibility nature of drug in the formulation. The drug release was up to 77.35% at the end of 3^rd hour.