System-on-Chip (SOC) is a microchip consisting of different components such as processor, memory and logic circuitry all on the same chip and for providing communication between these components on the chip Network-on-Chip (NOC) is required as the conventional interconnects are not suitable to fulfil the demands. The application of traditional network technologies in the form of Network-on-Chip is a possible solution. In this paper 4x4 mesh and 4x4 custom topologies of Network-on-Chip are examined and finally reached a conclusion that custom topology 2 is better than mesh topology as well as all the other custom topologies as custom 1 and custom 3 in terms of transmission time, throughput and packet delivery ratio.