1Psychiatry and Sleep Medicine, Ministry Health Care, St. Michael's Hospital, Stevens Point, WI, USA
2Clinical faculty, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
3Clinical Adjunct faculty, Medical College of Wisconsin-Central Wisconsin, Wausau, WI, USA
*Address for correspondence: Umesh Kumar Vyas, MD, FAASM, 1630 Okray Ave, Plover, WI, 54467, USA. Email: uvyaslife@yahoo.ca
Online published on 7 October, 2016.
To determine effects of quetiapine on polysomnographicrecorded sleep architecture and parameters.
Quetiapine receptor profile suggests that sleep-inducing and sleep-modifying properties may be causing changes in sleep architecture and parameter, which may have therapeutic value.
A cross-sectional retrospective study conducted at the sleep center. Polysomnographic sleep records were selected and reviewed from among patients who presented over 24-months for evaluation. Twenty-one patients were selected and matched based on age, sex, body-mass index (BMI), and the presence/absence of obstructive sleep apnea (OSA) to control subjects without quetiapine. Correlation analysis was performed to assess the association of quetiapine with sleep architecture and parameters.
Quetiapine was not significantly associated with altered sleep efficiency, sleep latency, wake time after sleep onset, or the relative percentage of sleep stages. A notablebut not significant (p = 0.08), increase in the rapid eye movement latency was observed.
Among the study population quetiapine was not found associated with changes in sleep architecture and parameters.
Quetiapine, polysomnography, sleep architecture and parameters
