A study of recovery from general anaesthesia after preoperative administration of antimicrobial

Antimicrobials are used prophylactily in any major surgery to cover perioperative wound infection and other infectious complication, that may have interaction with muscle relaxant used for general anesthesia and the aim of our study is drug interaction and behavioural response of newly introduced antibiotics used with rocuronium. Gentamicin shortened onset and duration of block after intubating dose of rocuronium and also prolonged duration of extubation after last dose of rocuronium where as meropenem and ceftriaxone did not alter onset, duration and recovery characterstics of rocuronium. From our study we can conclude that meropenem and ceftriaxone but not gentamicin, can be used safely during general anesthesia.