Intravenous conscious sedation in uncooperative children under going dental procedures: a comparative evaluation of Midazolam/Propofoland Ketamine/Propofol

There is a lack of clinical trials on pediatric dental sedation. We investigated efficacy of intravenous conscious sedation during dental treatment with Midazolam/Propofol compared to Ketamine/Propofol in 4–6 years old children. In this prospective clinical trial study 38 healthy non-cooperative children candidate dental treatment under Intravenous conscious sedation randomly were divided into two groups. Intravenous conscious sedation in one group was performed by midazolam/Propofol and in the other group carried out by Ketamine/propofol. The bispectral index and sedation score from Dental Sedation Teachers Group (DSTG) was employed for evaluating the sedation effect of each regimen by a one trained, blinded observer. The working conditions for each patient were assessed at the end of the treatment, using the rating scale by DSTG and the time taken to achieve discharge criteria was also recorded. Data analysis was performed using, variance analysis test for repeated data Friedman, Mann-Whitney and T-Test. Good sedation of the 2 groups after intravenous administration was observed. In midazolam/propofol group BIS index was higher than ketamine/propofol group but there was no statistical difference for sedation BIS index (PV=0.153). There was no statistical difference for sedation score, working condition and recovery time between children receiving midazolam/propofol or ketamine/propofol (PV>0.05). Midazolam/Propofol and Ketamine/Propofol, intravenous conscious sedation is efficacious forguiding the behavior of 4–6 years old children during dental treatment.