The role of serum vitamin B12 and homocysteine in recurrent pregnancy loss

The study was carried out from August 2012–2014 in Dr D. Y. Patil Hospital in the department of Obstetrics and Gynecology. 100 nonpregnant women with previous 2 or more abortions, attending OPD for bad obstetric history. They were subjected to serum B12, fasting serum homocysteine and folic acid measurements. Patients with B12 < 200 pg/ml and homocysteine >15mmol/dl were identified. They were substituted with oral vitamin B12 till B12 levels were normalized. After this, the patients were asked to go ahead with conception and their subsequent obstetric course was studied. The prevalence of B12 deficiency was found to be 40%. After subsequent B12 substitution, 36 women conceived out of which 2 women had a repeated miscarriage at 8 weeks(5.5%). Out of these 36 women, 25 have had live births so far, while 6 have crossed 20 weeks uneventfully and 3 have crossed 12 weeks uneventfully at the time this study went into print. It was seen that B12 values were significantly lower and homocysteine values were significantly higher in study group.