To evaluation of of uterine arterial blood flow in early pregnancy in women with recurrent pregnancy loss

A prospective observational study for evaluation of blood flow resistance in uterine arteries was conducted from March 2012 to April 2013. Around 120 pregnant women at 5 to 9 weeks gestation included and underwent transvaginal pulsed Doppler ultrasound (control group n= 60; and recurrent pregnancy loss group, n= 60). Blood tests for antinuclear and antiphospholipid antibodies were also performed. The uterine arterial pulsatility index in recurrent pregnancy loss group was significantly higher than that in control group. Women with antinuclear or antiphospholipid antibodies had an elevated pulsatility index in the uterine artery, which was prominent in women with recurrent pregnancy loss group. Coagulopathy and vascular dysfunction caused by autoantibodies may impair uterine perfusion. However, the uterine arterial pulsatility index in recurrent pregnancy loss group significantly higher than that in the control group even among women without antinuclear antibodies or antiphospholipid antibodies. This observational study suggests that the uterine artery pulsatility index may be an independent index for recurrent pregnancy loss(which is noninvasive evaluation of uterine impedance).