Synthesis, Characterization and Evaluation of substituted Benzimidazole hydrazine Carboxamide derivatives for Antiinflammatory activity

A series of Benzimidazole derivatives were synthesized by condensation of N-(1H-benzimidazol-5-yl)hydrazine carboxamide with various isatin derivatives and evaluated for their anti-inflammatory activity using carrageenan induced rat paw edema model. The synthesized compounds 7a-7h were characterized by spectral data (IR, 1H-NMR and mass) and elemental analysis. All the novel benzimidazole derivatives exhibited mild to moderate activity. Compound 7b, 5-methyl isatin derivative exhibited better anti-inflammatory activity compared with control and other test compounds with percentage inhibition of 71.75.