1Division of Biological Standardization, Indian Veterinary Research Institute, Izatnagar, Bareilly-243122.
2National Biotechnology Centre, Indian Veterinary Research Institute, Izatnagar, Bareilly-243122.
Abstracts of Research Papers Presented during the National Symposium of Indian Virological Society at Unit of Plant Virology, Division of Plant Pathology, Indian Agricultural Research Institute, New Delhi-110 012, October 14–1.
The capsid protein VP2 of canine parvovirus(CPV) isolated in India was used for modelling using SWISS-MODEL software online and viewed using Rasmol V 2.7.2.1.1 and Swiss PDB viewer (SPDV V3.7). It was observed that the VP2 capsid protein has different groups, which show the reactive sites on the protein. When various parameters were applied in the Swiss-model software, different groups like strand color group, ball and stick color group, ribbon color group, space-fill color group, wire frame color group could be seen. These model features showed clearly the reactive sites as well as grooves on the protein. The three dimensional protein structures are essential for the proper understanding of the molecular basis of protein function. Since VP2 is responsible for neutralizing antibody which gives protection, the epitope groups seen in the model structure could be the antigenic sites for neutralising antibody.
