CD8 T cells are critical for the clearance of intracellular pathogens. Upon infection of the host, naïve CD8 T cells differentiate into effector cells that target and eliminate infected cells. Following clearance of the pathogen, a majority of effector cells die, while a small fraction survives to establish a memory population. Subsequent exposure to the same pathogen induces rapid proliferation and differentiation of memory T cells and efficient elimination of the invading pathogen. Although much is known about the activation and differentiation of CD8 T cells, the precise microevironmental location of effector and memory CD8 T cells in secondary lymphoid organs is not well characterized. Here we present an
