1Experimental Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695 012, Kerala, India
2Polymer Processing Laboratory, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695 012, Kerala, India
3Toxicology Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695 012, Kerala, India
4Division of Artificial Organs Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695 012, Kerala, India
†Corresponding author. E-mail: somvanshi@gmail.com
Implant pathology of polyvinylidene fluoride (PVDF) coated polyethylene terephthalate fabric (PET) was studied in rabbits. The tissue response to the coated fabric was compared with that of an uncoated commercial biomaterial-grade fabric. The coating was aimed at enhancing the potential of PET for biomedical applications. The histopathologic response to PVDF-coated and uncoated fabric was similar in the rabbit model. Both these materials evoked chronic inflammation, fibrosis, granuloma and giant cell reaction. Quantification of the nature of tissue response was performed as per international norms. When assessed by international standards, the PVDF coated fabric was found biocompatible in view of specific applications of the biomaterial.
Implant pathology, Biomaterials, Surface modification, Polyvinylidene fluoride, Polyethylene terephthalate)
