Studies on haemato-biochemical changes in Pasteurella multocida serotype A: 1 infection in mice

Haemato-biochemical changes were studied in nine groups of mice, which were experimentally infected by Pasteurella multocida serotype A: 1 and sacrificed at different hours post-infection (HPI). A transient leukocytopenia at early HPI and progressive leukocytosis at later HPI were observed in all the infected animals. An increase in thrombocyte and decrease in total erythrocyte counts were observed, but the changes were not statistically significant between the infected and control group animals. In differential leukocyte counts, a progressive neutrophilia and corresponding lymphocytopenia were observed throughout the course of infection. Monocytosis was observed in animals of all infected groups, while there were no changes in basophil and eosinophil counts. Among different erythrocytic indices, the changes were observed only in PCV, Hb, MCHC and MCH values. An increased total protein and albumin: globulin ratio was observed, whereas the level of plasma fibrinogen and other serum biochemical values remained normal in animals of infected groups.