Indian Journal of Veterinary Pathology
Open Access
  • Year: 2007
  • Volume: 31
  • Issue: 2

Mixed hepatocellular and cholangiocarcinoma in a Himalayan brown bear (Ursus arctos isabellinus)

  • Author:
  • M.M. Darzi1,, M.S. Mir1, T.A.S. Ganai2,4, N. Nashiruddullah1,4, Mir Mansoor3,4, S.A. Kamil1,4
  • Total Page Count: 3
  • Published Online: Dec 1, 2007
  • Page Number: 163 to 165

1Divisions of Veterinary Pathology, Srinagar, Kashmir,

2Animal Genetics & Breeding, Srinagar, Kashmir,

3State Wildlife Department, Srinagar, Kashmir,

4Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology Kashmir Shuhama (Alusteng), Srinagar-190 006 (J&K)

*Corresponding author.

Abstract

Mixed hepatocellular and intrahepatic biliary carcinoma was identified in an 18-year-old male Himalayan brown bear (Ursus arctos is abellinus) in Dachigam National Park at Srinagar, Kashmir. Clinically, the animal showed progressive emaciation and respiratory distress. Necropsy revealed hepatomegaly with yellowish-white to grey nodular growth of 24×25×23cm size weighing about 10 Kg, which was histologically suggestive of mixed hepatocellular and biliary carcinoma having a mitotic index of 4–5 and argyrophilic nucleolar organizer region (AgNOR) index 10.25±1.75.

Keywords

Apoptosis, Hepatocellular carcinoma, Liver, Nucleolar organizer region, Ursus arctos isabellinus