Quantification of microscopic lesions in nervous tissue of rabid buffaloes and cattle

The nervous tissues of 47 rabid buffaloes and 23 rabid cattle were assessed quantitatively by study of histopathological alterations. There was significant detection of Negri bodies in cerebellum both in cattle (91.3%) and in buffaloes (85.1%), however, in case of cerebrum, Negri bodies were found more in buffaloes (65.95%) than in cattle (13.0%). Thus, in case of nonavailability of cerebellum, Negri body detection of Negri body could be attempted only in buffalo while it would not be reliable approach in cattle. However, reactive inflammatory response was more consistently present in brainstem than in cerebrum and cerebellum of rabid buffaloes and cattle. Similarly, malacia was more consistent finding in buffaloes (51:6%) than in cattle (26.08%).