Indian Journal of Veterinary Pathology
Open Access
  • Year: 2009
  • Volume: 33
  • Issue: 1

Appearance of Heinz bodies in phenylhydrazine-exposed chicken erythrocytes: an overview of mechanisms

  • Author:
  • Kabita Roy1,, M. A. Quadri2, I. C. Datta2, Sabita Rakshit3
  • Total Page Count: 3
  • Published Online: Jun 1, 2009
  • Page Number: 96 to 98

1Departments of Veterinary Medicine

2Biochemistry, College of Veterinary Science and Animal HusbandryJawaharlal Nehru Krishi Vishwa Vidyalaya, Jabalpur-482001 (M.P.)

3Division of Molecular Medicine and Genetics, Department of Internal Medicine, Medical Center University of Michigan, Ann Arbor-48201-2200, MI, USA

*Corresponding author.

Abstract

Heinz bodies were the cytosolic hallmark of in vivo/in vitro phenylhydrazine-hydrochloride (PHH) exposed chicken erythrocytes. Concomitant morphological aberrations were also discernible. This cytotoxic episode appeared to be the culmination of a cascade phenomenon, triggered by superoxide anion (O2−). Documented experimental evidence further suggested that, among several toxic oxygen derivatives, reactive hydroxyl radical (OH−) and hydrogen peroxide (H2 O2) also significantly contributed to the induced micro-architectural anomolies, perceptible in the red blood cells.

Keywords

Chicken erythrocytes, Haemoglobin oxidation, Heinz bodies, Mechanisms