Histopathological changes in induced fenvalerate toxicity in rats and its amelioration with Withania somnifera

In the present study rats were randomly divided into eight groups. Rats of groups n, HI and IV were treated with different doses of fenvalerate and ashwagandha was given orally @ 200mg/Kg b.wt. to V, VI and VII groups of rats along with fenvalerate over a period of 6 weeks. Group I and Vm were kept as oil control and ashwagandha control and histopathological changes were studied in different organs. Dose dependent changes were noticed in all organs. In kidneys congestion, edema, degenerative changes, intertubular haemorrhages, mild fatty changes in tubular epithelial cells were observed in majority of higher doses of fenvalerate treated rats. Liver revealed congestion, degenerative changes, haemorrhages, mild fatty changes, infiltration of mono nuclear cells, loss of hepatocytes and proliferation of bile ducts in all fenvalerate treated groups. Lungs of higher doses of fenvalerate treated groups revealed moderate to severe congestion, edema, perivascular and peribronchiolar infiltration of mononuclear cells and hypertrophy of lymphoid follicle. Histopathologically cerebrum revealed congestion, submeningeal haemorrhages and demyelinating changes in all fenvalerate treated groups. Based on changes it was concluded that fenvalerate at 42.5 mg/Kg b.wt. for 6 weeks was moderately toxic to rats and ameliorative effect of ashwagandha was less and observed only in lower dose levels of fenvalerate.