Indian Journal of Veterinary Pathology
  • Year: 2010
  • Volume: 34
  • Issue: 2

Effect of N-acetyl-thiazolidine-4-carboxylic acid on liver enzymes and lipid peroxidation in carbon tetrachloride induced toxicity in rats

  • Author:
  • M. Ganguli4, P. Deb4, S. Ganguly1,4, S.K. Mukhopadhayay4,, J. Hazra2,4, S.N. Upadhyay2,4, D. Niyogi3,4
  • Total Page Count: 3
  • Published Online: Dec 1, 2010
  • Page Number: 213 to 215

1AICRP on Post Harvest Technology in Department of Fish Processing Technology, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata-700 037

2National Research Institute of Ayurveda for Drug Development, Kolkata,

3Department of Veterinary Pathology, College of Veterinary Science & Animal Husbandry, Narendra Deva University of Agriculture and Technology, Faizabad

4Department of Veterinary Pathology, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata-700 037

*Corresponding author; e-mail: skmpath@gmail.com

Abstract

The present study indicated that N-acetyl-thiazolidine-4-carboxylic acid could not nullify the toxicological effect of carbon tetra-chloride in liver of rat. Further, hepatotoxic activity of carbon tetrachloride was aggravated by N-acetyl-thiazolidine-4-carboxylic acid whenever both were used in combination therapy. Besides, N-acetyl-thiazolidine-4-carboxylic acid alone produced mild hepatotoxic activity in rats, so it was concluded that N-acetyl-thiazolidine-4-carboxylic acid was not a hepatoprotective agent in rat.

Keywords

Carbon tetrachloride, Hepatotoxic, Liver, N-acetyl-thiazolidine-4-carboxylic acid