1department of Pathology,Nagpur Veterinary College, Maharashtra Animal & Fishery Sciences UniversityNagpur-440006,
22Ventri Biologicals Vaccine Division, V.H. Ltd., Pune
3Department of Microbiology,Nagpur Veterinary College, Maharashtra Animal & Fishery Sciences UniversityNagpur-440006,
*Corresponding author: email: nitinkurkure@rediffmail.com
The immunogenicity and protective capability of D, L-±-tocopheryl acetate (vitamin E) adjuvanted Newcastle disease (ND) + Infectious bursal disease (IBD) inactivated vaccine was evaluated in broiler chicks. Results showed that the vaccine supplemented with vitamin E induced more rapid and higher antibody response than control vaccines. Post challenge with virulent ND and IBD virus, absolute protection was recorded in chicks earlier vaccinated with ND + IBD vaccine containing adjuvant replaced with 20 and 10 per cent vit. E, respectively. Post challenge gross and histopathological lesions were minimum in-group vaccinated with vitamin E adjuvanted vaccine. Our results provide an evidence that vitamin E can be used efficiently as component of inactivated ND + IBD vaccine to induce protective immune response in birds.
Adjuvant, Immune response, Vaccine, Vitamin-E
