Pathology of chronic interstitial pancreatitis in Beagle dogs

Three cases (male-2 and female-1) of chronic interstitial pancreatitis were recorded in 6–12 months old Beagle dogs out of 178 necropsies. Grossly, the pancreas was hard, grayish pale in color and smaller in size when compared with pancreas of other dogs of same age group. Histomorphology revealed dense fibrous capsule. Pancreatic parenchyma was divided/subdivided into small lobes and lobules by thick fibrous septae. In addition, acinar atrophy and degeneration/necrosis, mononuclear cell infiltration, hyperplasia of interlobular ducts and periductal fibrosis with ductectasis. Islets of Langerhans appeared uninvolved.