Comparative analysis of histopathological alterations of rabies in cows, buffaloes and dogs

In the present study, histpathological alterations in nervous tissue of 8 dogs, 5 cows and 7 buffaloes were analyzed. Sensitivity of histpathological alterations was compared with immunofluorescence (FAT). On the basis of Negri body detection and histomorphological alterations rabies was confirmed in 11 (55%) cases constituting of 2 dogs, 5 cows and 4 buffaloes while, FAT detected rabies viral antigen in 13 (65%) cases consisting of 4 dogs, 5 cows and 4 buffaloes. Sensitivity of histpathological study as compared with FAT was found to be 86.67%. Quantitative assessments of other histpathological alterations reported were perivascular cuffing, neuronal degeneration, gliosis, congestion, hemorrhages, neuronophagia, satellitosis and meningitis.