Effect of cow urine against experimental E. coli infection in rats: A histopathogical study

The work was conducted on experimental rats which were fed cow urine and challenged with E.coli infection. Pathomorphological examination of rats succumbed to infection revealed changes of acute non- suppurative hepatitis characterized by paracentral/centrilobular necrosis with infiltration of neutrophils and macrophages; thickening of alveolar septa due to congestion of blood vessels with peribronchial lymphoid cuffing; congestion of myocardial blood vessels and at places separation of myofibres with degeneration myocardium; slightly swollen, dark brown kidneys showing congested corticomedullary junction with increased cellularity and vacuolization of glomerular loops along with tubular degeneration and thickened intestinal wall with congestion along with presence of catarrhal to haemorrhagic exudates. The above pathomorhpolgical changes in various organs were more severe in the rats of control group as compared to the rats of urine treated group.