Histopathological and immunohistochemical study of hemangiosarcoma in lions

Two cases of hemangiosarcoma were recorded in lion during postmortem examination. Grossly, multiple variable sized reddish black hemorrhagic foci were noticed in the liver and spleen parenchyma. Histopathologically foci of liver and spleen revealed necrosed and numerous blood filled areas. Immature, plump endothelial cells forming vascular spaces and irregular vascular spaces containing variable amounts of blood were noticed. Immunohistochemically there was increased expression of vascular endothelial growth factor in endothelial cells.