1Animal Disease Research Centre, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India
2Department of Teaching, Veterinary Clinical Complex, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India
3Department of Veterinary Pathology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India
*Corresponding author: email: mmaulivet@gmail.com
BRCA1 is regarded as putative tumor suppressor gene. This gene and its proteins are involved in the regulation of various critical steps of a cell cycle. A number of studies strongly suggest that the loss or aberrant expression of BRCA1 is associated with tumor formation. The present study was designed to investigate the immunohistochemical expression of BRCA1 in 31malignant canine mammary tumors (CMTs). Out of 31 cases, 26 cases showedcytoplasmic expression BRCA1 expression, whereas, in 5 casesno BRCA1 expressionwas observed. In addition, the BRCA1 expression was aberrant, as it was noticed in cytoplasm instead of nuclei of the tumor cells. The results of this study indicated that the loss or aberrant expression of BRCA1 might be associated with malignancy, and thus poor prognosis in CMTs.
Aberrant expression, BRCA1, Canine mammary tumor, Immunohistochemistry, Tumor suppressor
