Evaluation of progression and regression stages of canine transmissible venereal tumour using cell proliferation markers

Sixteen dogs with canine transmissible venereal tumour (CTVT), which is high frequency round cell tumour of dogs, were treated with either vincristine or doxorubicin to study the cell proliferation markers like mitosis and agyrophilic nucleolar organizer regions (AgNOR) during the progression and regression stage of the tumours. Expression of these markers were decreased during the early and late regressive phases of CTVT, indicating that these aspects can be successfully utilized in the diagnosis, prognosis and chemotherapy of CTVT.