Comparative hepatoprotective effects of Berberi slycium, Tinospora cordifolia and Hippophae salicifolia against lantadenes-induced hepatotoxicity in guinea pigs

The hepatoprotective activity of freeze-dried methanolic extracts of three herbal plants including Berberi slyciumroot bark, Tinospora cordifolia stem and Hippophae salicifolia leaves were evaluated against lantadenes-induced hepatic damage in guinea pigs. A total of 36 guinea pigs of either sex were divided into 9 groups. The oral administration of two graded doses of freeze-dried methanolic extract of the ameliorating plants (100 and 200 mg/kg bw) was started a week prior to the administration of lantadenes (at the dose of 25 mg/kg bw). The total duration of the trial was 21 days. The results of gross and histopathology suggested that amongst the three herbal plants, B. lycium was the most effective herbal plant in preventing lantadenes-induced damage in a dose-dependent manner. This was followed in decreasing order by the higher dose of T. cordifolia. Amongst all the three plants, methanolic extract of H. salicifolia appeared to be noneffective plant against lantadene-induced hepatotoxicity.