Histopathological and immunohistochemical study of extra skeletal chondrosarcoma in lion (Panthera leo)

A hard greyish white coloured growth was detected in the lower region of the abdomen near the sternum in a 23-year-old male lion (Panthera leo) and was examined histopathologically and immunohistochemically. After routine processing, tissues were subjected to hematoxylin and eosin stain and to the marker, VEGF. The mass was composed of numerous pleomorphic chondrocytes within the basophilic matrix. The mean AgNOR value obtained was 4.49. The expression of VEGF in the cytoplasm of the neoplastic cells was noticed. Based on the histopathological features and the strong cytoplasmic reactivity of VEGF, the present case was diagnosed as extra skeletal chondrosarcoma.