1Centre for Wildlife Conservation, Management and Disease Surveillance, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India
2Division of Surgery, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India
3Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India
*Address for Correspondence Anil Kumar Sharma, Principal Scientist, Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India, e-mail: aksharmaivri@rediifmail.com
The p53 protein expression is considered as a poor prognostic indicator in canine mammary carcinomas, but the relevance of TP53 gene expression is not studied much. In the present study, the TP53 gene expression levels were evaluated by quantitative realtime RT-PCR in 22 canine mammary tumours. The correlation of the gene expression with tumour size, histological type and mitotic count were assessed. Among the 22 tumours, 5 were benign and 17 were malignant. On statistical analysis, the gene expression did not show any significant difference with tumour size, type (benign and malignant) and histological type whereas differed significantly with the mitotic count.
How to cite this article: Sreelekshmy, M., War, Z.A., Karikalan, M., Mohan, D., Chandra Mohan, S., Kumar, P. and Sharma, A.K. (2019). TP53 gene expression in benign and malignant canine mammary tumours. Indian J. Vet. Pathol., 43(2): 136–139.
Canine mammary tumours, Gene expression, Realtime RT-PCR, TP53
