1Department of Veterinary Pathology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar-125 004, Haryana, India
2Department of Veterinary Microbiology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar-125 004, Haryana, India
*Address for correspondence Dr Sonu Sharma, Department of Veterinary Pathology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar-125 004, Haryana, India, E-mail: sonusharmavet@gmail.com
Online published on 12 October, 2020.
The present study communicates the pathomorphological features and immunohistochemical expression of p53 and pan-cyto- keratin in 16 cases of bovine epithelial tumors. Histopathologically, these were diagnosed as papilloma, squamous cell carcinoma (SCC) and adenoma. Papillomas located on various parts of skin were characterized by outward papillary projections of stratified squamous epithelium having connective tissue in centre. SCCs were classified as differentiated or undifferentiated types. Well differentiated SCCs were characterized by islands of stratified epithelium, cell nests, pleomorphic hyperchromatic nuclei and occasionally mitotic figures, while poorly differentiated SCC showed tumor islands but devoid of cell nests. Undifferentiated SCCs noticed in eyes or horn revealed group of epithelial cells with variable morphological features arranged as cords or islands without keratinized layer in centre and numerous mitotic figures. Variations in pattern of nuclear p53 immunoreactivity were noticed among different SCCs. p53 immunoreactivity was not noticed in benign epithelial tumors. All tumors showed cytoplasmic pan-cytokeratin immunoreactivity with variable staining intensity. It is concluded that undifferentiated epithelial tumors can be confirmed by pan-cytokeratin immunostaining and p53 expression is more in malignant than benign SCCs.
Bovine, Epithelial tumors, Immunohistochemistry, Pan-cytokeratin, P53
