Indian Journal of Veterinary Pathology

  • Year: 2020
  • Volume: 44
  • Issue: 2

Toxicopathological effects of siddha drug thamira kattu chendooram in Wistar rats

  • Author:
  • R. Madheswaran1,*, G.A. Balasubramaniam, P. Srinivasan, K. Sukumar2, S. Kathirvel3, T. Lakshmi Kantham4, C. Balachandran5
  • Total Page Count: 4
  • Published Online: Jun 1, 2020
  • Page Number: 132 to 135

1Department of Veterinary Pathology, Veterinary College and Research Institute, Namakkal-637002, Tamil Nadu, India;

2Department of Veterinary Microbiology, Veterinary College and Research Institute, Namakkal-637002, Tamil Nadu, India;

3Department of Veterinary Surgery and Radiology, Veterinary College and Research Institute, Namakkal-637002, Tamil Nadu, India;

4Department of Maruthuvam, National Institute of Siddha, Tambaram Sanatorium, Chennai-600047, Tamil Nadu, India;

5Tamil Nadu Veterinary and Animal Sciences University, Madhavaram Milk Colony, Tamil Nadu, Chennai-600051, India

*Address for correspondence Dr R. Madheswaran, Assistant Professor, Department of Veterinary Pathology, Veterinary College and Research Institute, Namakkal-637002, Tamil Nadu, India, E-mail: rmadheswaran2003@gmail.com

Online published on 19 October, 2020.

Abstract

A 28-day repeated dose toxicity study was conducted to evaluate the toxicity of thamira kattu chendooram (TKC) in Wistar rats. Thirty two male rats were randomly distributed eight each into four groups of control, low, mid and high dose. Rats were treated with different doses of TKC for 28 days. Reduced body weight and feed consumption were noticed in the mid and high dose groups. Blood samples were collected for haemato-biochemical analysis at the end of the study. Haematological parameters revealed decreased total erythrocyte count, haemoglobin and packed cell volume in high dose group. Alterations of serum biochemical values were noticed in glucose, total protein, albumin and magnesium. Gross and histopathological examinations did not reveal any treatment related changes.

Keywords

Haemato-biochemistry, Histopathology, TKC, Wistar rats