Clinico-haemato-biochemical and oxidative stress evaluation of hepato-renal dysfunction in dogs with total cholesterol as a biomarker for hepatic diseases

A disturbance will be seen in lipid production and utilization in case of a pathogenic process, involving liver, as it is the site of processing of lipid components. Dyslipidemias such as hypocholesterolaemia are reported in humans as markers of case recovery and survival, in liver dysfunction, but there is scanty literature for the same in dogs. Hence, the current study involves hemato-biochemical and oxidative stress evaluation in hepato-renal dysfunction in dogs with evaluation of total cholesterol as a marker for hepatic diseases. Approximately 150 dogs, presented at TVCC, College of Veterinary Science and Animal Husbandry, Jabalpur, were classified based on subsequent clinical signs for hepatic and renal dysfunction and subjected for haematological and biochemical examination. They were divided into three groups (n=13) based on the serum biochemical analysis and compared with a control. No significant difference was observed in haematological examination in case of separate affections of liver or kidneys but it was seen in mixed organ involvement. Hepatic involvement showed an increase in values of serum enzymes along with hyperbilirubinemia and drop in albumin while renal involvement showed increase in serum creatinine and blood urea nitrogen levels. The mean values of serum total cholesterol (CHO) were found to be significantly lower in animals having hepatic involvement i.e. hepatic group (CHO = 116.03±59.82 mg/dl) and hepatorenal dysfunction (CHO = 172.04±102.61) when compared with control range (180.80 - 260.90 mg/dl). Group with primary renal dysfunction showed a normal mean value with CHO = 200.65±48.94 mg/dl. Thus, the fall in levels of cholesterol in cases of hepatic involvement could signify hypocholestero-laemia as a marker of hepatic disease or dysfunction in dogs.