Pathomorphological and immunohistochemical studies on rare case of liposarcoma in oral cavity of a buffalo

Liposarcomas are reported in domestic animals, but occurrence is rare. These tumours are very rare in oral cavity of large domestic animals. This study describes the pathomorphological and immunohistochemical observations of a rare case liposarcoma in oral cavity of a seven years old buffalo. Within the oral cavity buffalo showed a large soft tissue growth in the left pre-molar region. On gross examination, it appeared yellow to greyish white and revealed multi-lobulations. Histopathologically, it revealed liposarcoma characterized by pleomorphic fat cells separated by fibro-collagenous stroma. The cells were characterized by pleomorphic nuclei with single to multiple prominent nucleoli and scanty cytoplasm. Mitotic figures were infrequent. Immunohistochemistry revealed intracytoplasmic reactivity for vimentin, but it did not reveal immunopositive reaction for pancytokeratin. At places, mild to moderate immunoreactivity for proliferating cell nuclear antigen was observed in the nuclei of proliferating lipocytes as well as in the stromal cells. To the best of authors’ knowledge and literature cited, this is the first report of liposarcoma in oral cavity of buffaloes.