Indian Journal of Veterinary Pathology

  • Year: 2023
  • Volume: 47
  • Issue: 3

Electron microscopic studies on hexavalent chromium toxicity in female Wistar rats

  • Author:
  • Mylaram Jeevana Latha*, M. Lakshman1, A. Anand Kumar2, A. Gopal Reddy3, D. Pramod Kumar4
  • Total Page Count: 4
  • Published Online: Oct 31, 2023
  • Page Number: 233 to 236

Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, PV Narasimha Rao Telangana Veterinary University, Hyderabad-500 030

1I/C RUSKA Labs

2College of Veterinary Science, SVVU, Tirupati

3PVNRTVU, Rajendranagar, Hyderabad

4Department of Anatomy and Histology, College of Veterinary Science, Rajendranagar, PV Narasimha Rao Telangana Veterinary University, Hyderabad-500 030

Abstract

Hexavalent chromium is a potent toxic agent found to be carcinogenic in human and animals. An experiment was conducted for a period of four months with 120 female wistar rats. These were maintained under standard management conditions with feed and water ad libitum throughout the experiment. These rats were divided into six groups. Group I was provided with routine basal diet. Group II with potassium dichromate @ 500 ppm, whereas group III was supplemented with vitamin C @ 100 mg/kg body weight. Group IV was provided with Emblica officinalis powder @ 2% in feed, group V and VI was provided with ameliorative diets. A detailed necropsy was conducted and organs like uterus, fallopian tube and ovaries were collected for ultra structural studies. The investigation revealed that there is a great damage to cellular and sub cellular structures in toxin group (II) where as a distinct amelioration is observed in ameliorative groups.

Keywords

Chromium toxicity, Female wistar rats, Ultra structural changes