Hepatocellular and bronchogenic carcinoma in a rabbit (Oryctolagus cuniculus): A case report

An adult male rabbit was presented for necropsy in the Department of Veterinary Pathology, DGCN COVAS, Palampur. The post-mortem examination of the rabbit revealed the presence of multiple nodular growths on the liver along with multiple pea-sized nodular and raised dirty fluid-filled cystic structures on the lung parenchyma. Fine needle aspiration cytology (FNAC) examination has shown the presence of pleomorphic cells with increased nuclear-cytoplasmic ratio and profound cellular atypia. The histopathological evaluation revealed the presence of pleomorphic hyperchromic neoplastic cells with prominent changes in nuclear components (anisokaryosis, prominent nucleoli) in hepatocytes and air spaces in lungs were filled with eosinophilic fluid as well as pleomorphic neoplastic cells. The present case was diagnosed to have died of hepatocellular and bronchogenic carcinoma based on macroscopic, cytological and histological examinations.