1Division of Toxicology & Experiment Medicine, CSIR-Central Drug Research Institute, Lucknow-226 031, Uttar Pradesh
2Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201 002
3Department of Forensic Science, Parul Institute of Applied Science, Parul University, Vadodara-391 760, Gujarat, India
*Address for Correspondence V.M. Prajapati, Senior Scientist, Division of Toxicology & Experiment Medicine, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow-226 031, India, E-mail: viren.prajapati.cdri@csir.res.in
Online published on 11 August, 2025.
The present study was conducted to learn about the various pathological changes due to folic acid-induced Renal changes in mice, which is a widely used experimental model to study the mechanisms underlying kidney fibrosis. Following high-dose folic acid administration, acute kidney injury is rapidly induced, primarily affecting the tubular epithelium. Clinical pathology, macroscopic, and microscopic changes with Hematoxylin & Eosin and special stains such as Masson Trichrome Stain fibrous tissue proliferation. Along with fibronectin, α-SMA, and Smad expression in the progression of Kidney fibrosis. Taken together, our findings might serve as a rationale for developing prospective innovative renal fibrosis. This present study's finding serves as a pathological change with the marker identification, affecting Renal disease progression.
Acute kidney injury, Chronic kidney disease, Folic acid, Nephropathy, Renal fibrosis
