1Department of Veterinary Pathology, College of Veterinary & Animal Science, Sri Venkateswara Veterinary University, Tirupati-516 360, Andhra Pradesh
2CVSc., Proddatur, Sri Venkateswara Veterinary University, Tirupati-516 360, Andhra Pradesh
3CVSc.Garividi, Sri Venkateswara Veterinary University, Tirupati-516 360, Andhra Pradesh
*Address for Correspondence: M. Ganesh Teja Naik, Department of Veterinary Pathology, College of Veterinary & Animal Science, Sri Venkateswara Veterinary University, Tirupati-516 360, Andhra Pradesh, India; E-mail: ganeshmude3399@gmail.com
Online Published on 09 January, 2026.
Brucellosis, a zoonotic disease caused by Brucella spp., significantly impacts the health and productivity of sheep, leading to economic losses and public health concerns. This study evaluated the hematobiochemical alterations in sheep affected with brucellosis in Anantapur district, Andhra Pradesh, India. A total of 100 serum samples from 100 animals (50 male and 50 female) were collected and screened for brucellosis using the Rose Bengal Plate Test (RBPT) and Indirect Enzyme-Linked Immunosorbent Assay (I-ELISA), revealed seroprevalence rates of 16% and 30%, respectively. Hematological and biochemical analyses were conducted on 20 seropositive sheep, with results compared to seronegative controls. Significant hematological changes (P<0.01) included reduced hemoglobin, packed cell volume and total erythrocyte count, accompanied by increased total leukocyte count, neutrophils and eosinophils. Lymphocytes, monocytes and basophils were reduced. Biochemical profiles showed elevated aspartate aminotransferase and alanine aminotransferase with decreased total protein and albumin (P<0.05).
ALT, AST, Brucella, Hemoglobin, I-ELISA, Neutrophils, PCV, RBPT
