The Indian Journal of Veterinary Research
Open Access
  • Year: 2006
  • Volume: 15
  • Issue: 1

Ipomeamarone induced hepatotoxicity in rats: A pathological evaluation

  • Author:
  • Govind Pandey1, D.N. Srivastava1, A.B. Shrivastav, Madhuri Sharma
  • Total Page Count: 6
  • Page Number: 40 to 45

1Faculty of Pharmacy, Shri Ram Institute of Technology, Jabalpur

Department of Pharmacology & Toxicology, College of Veterinary Science & Animal Husbandry, Jabalpur (MP) - 482001

*Corresponding author: Faculty of Pharmacy, Shri Ram Institute of Technology, Jabalpur.

Abstract

An experimental model of hepatotoxicity was produced by ipomeamarone (IPM) in rats. Oral administration of IPM after one month (125, 250 and 500 mg/kg), four months (250 and 500 mg/kg) and eight months (500 and 1000 mg/kg) of isolation damaged the liver within 48 hr. Liver tissues revealed varying degrees of congestion, degeneration and necrosis. The severity and extent of liver damage appeared to be dose dependent. The oral hepatotoxic dose of IPM producing standard liver damage was found to be 250 mg per kg body (after one month of isolation). The hepatotoxicity was characterized by periportal, centrilobular or midzonal necrosis.

Keywords

Histopathological changes, Ipomeamarone, Liver damage