Department of Chemistry, Faculty of Science, Dayalbagh Educational Institute, Dayalbagh, Agra - 282005 (Uttar Pradesh).
The antihyperglycemic and antioxidative potential of the plant Coccinia indica was assessed in alloxan induced diabetic rats. Lipid peroxidation was measured in normal, diabetic and treated animals. Blood sugar and lipid peroxidation level were higher and antioxidant level was found low in diabetic group from the normal group. A significant alteration in the blood sugar, malondialdehyde (MDA) levels and antioxidant activity was observed in diabetic animals exposed to ethanolic leaf, ethanolic leaf +alpha lipoic acid (ALA) and glibenclamide for 15 consecutive days. Coccinia indica not only reduced the oxidative stress but also strengthened the antioxidative potential.
Alpha lipoic acid, Antioxidant activity, Coccinia indica, Diabetes, Leaf extract, Oxidative stress
