Biochemical changes in the gradual process of urethral obstruction and its release in caprine

The study was conducted in twelve apparently healthy male non-descript goats aged between 1.5–2 years. In group one partial urethral obstruction created by performing urethrotomy and subsequent closure of urethra after placing a small bored (more than 1 mm diameter) catheter. The surgical site was reopened after 5 days and complete urethral obstruction was achieved by ligating the base of urethral process. Subsequently, after two days of complete obstruction, the surgical site was again reopened and obstruction was released. The animals were maintained up to 14 day. In group two, only surgical intervention was done without manipulating the urethra and this group served as control. The serum urea nitrogen and creatinine were elevated significantly during the partial and complete urethral obstruction when compared to control group. Serum inorganic phosphorus and potassium values also showed a gradual increase from day zero to day seven (release of obstruction) and subsequent decrease towards normal values by fourteenth day. Hypoglycemia was observed during the period of partial and complete obstruction which varied significantly when compared to control group.