Department of Surgery and Radiology, College of Veterinary Science and Animal Husbandry, Jabalpur-482 001, (M.P).
2 Corresponding Author- Department of Veterinary Medicine
1Present address: Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical Center, An Arbor 48109-2200, MI USA. E-mail srakshit@med.umich.edu
An early declining trend in haemoglobin concentration, concurrent with reduced total erythrocyte count and PCV% was observed with pentazocine or lysine acetyl salicylate (LAS) analgesic pre-medication in thiobarbiturate intravenous general anaesthesia in atropine-primed normal dogs. While the declining trend in PCV% persisted with pentazocine, it had abated at 1.5 hr with LAS pre-medication. No evidence of intravascular haemolysis or red cell morphological aberration was found. Alterations in the values of major haematological indices appear to be a passive consequence of volume changes in the splenic pulp: initial dilatation induced by the thiobarbiturate followed by spontaneous contraction back to original biometry. The observed early lymphopoenic-eosinopoenic response might reflect enhanced glucocorticoid titre during the anaesthetic stress.
Analgesic pre-medication, Dogs, Haematological response, Thiobarbiturate anaesthesia
