Hypolipidemic potential of Oscimum sanctum in induced arsenic toxicity

The study evaluated the ameliorative potential of hydro methanolic extract of Oscimum sanctum leaves against sodium arsenate induced hyperlipidemia in experimental rats. Animals were divided into five groups of 15 rats in each. Control group exposed to arsenic free distilled water and 4 treatment group (II, III IV, V) exposed to the arsenic (NaAsO₂) (20mg/kg b.wt) through drinking water. Group III to V were administered a daily oral dose of HAEO (Hydro alcoholic extract of Oscimum sanctum) @50, 100 and 200mg/kg b.wt. orally daily for a period of 45 days. Blood samples were collected fort he estimation of lipid profile, after every 15days interval till the completion of the trial.. Arsenic exposure resulted in significant (P<0.05) rise in total and LDL-cholesterol whereas decreased HDL cholesterol was observed. Blood triglyceride levels were found increased in arsenic intoxicated animals as compared to control animals. Treatment with HAEO₁₀₀ and HAEO₂₀₀ significantly restored level of lipid profiles.