In vivo immunostimulatory effects of alcoholic extract of Tinospora cordifolia against CdCl₂-induced immunosuppression in mice

The present study was done to assess the immunomodulatory and ameliorative potential of Tinospora cordifolia against CdCl₂ intoxicated Swiss albino mice. Fifty mice were divided into five groups of ten each where group I served as control, group II treated with 100 ppm of CdCl₂ every alternate day for six weeks and group III, IV and V were initially treated with methanolic extract of T. cordifolia @100, 250 and 500 mg/kg body weight for first two weeks. From second week onwards group III, IV and V were treated with T. cordifolia extract at above mentioned dose rates along with additional supplementation of 100 ppm of CdCl₂ for next four weeks making a total duration of experiment to be six weeks. Positive effects were observed on both cellular as well as humoral immune responses with improved oxidant-antioxidant balance in the treatment groups showing promising immunostimulatory effects of methanolic extract of T. cordifolia.