Efficacy of some chemotherapeutic drugs against Theileria annulata infection in crossbred calves

The efficacy of four chemotherapeutic agents namely Diaminazine aceturate along with Oxytetracycline, Buparvaquane and Chloroquine was ascertained in calves experimentally infected with Theileria annulata. The results indicated that the Buparvaquane was found to be 100% effective under experimental conditions. The single dose therapy was found effective in eliminating the protozoan parasites from the blood with breakdown of subclinical carrier stage of theileriosis. The animals trial with Diaminazine aceturate along with Oxytetracycline also recovered but repetition of the treatment was required to eliminate the carrier state in subclinically infected animals. while Chloroquine proved to be totally non effective against T. annulata infection.