Use of oxidized regenerated cellulose and dextran-40 as adhesioprophylactic agents: An experimental study

This study was based on the comparison of 2 leading approaches in abdominal adhesion prophylaxis i.e. barrier technique (Oxidized regenerated cellulose) and chemical method (10% Dextran-40) on 18 apparently healthy male mongrel dogs divided equally in 3 groups. A standardized trauma was produced on the jejunum of all animals, for creating adhesions. Dextran-40 was instilled in abdominal cavity and oxidized regenerated cellulose was used topically, as adhesioprophylactic agents before closure of skin incision. Dextran-40 was found to be more effective in preventing abdominal adhesions than oxidized regenerated cellulose when examined grossly and microscopically.