Effect of lipid-free propofol anaesthesia on clinical and physiological parameters in dogs

Eighteen adult dogs of either sex were randomly divided into three groups of six animals each. Animals of group I were given lipid-free propofol alone (5 mg/kg), group II triflupromazine hydrochloride (1 mg/kg) and lipid free propofol (3 mg/kg), and animals of group III diazepam (0.5 mg/kg) and lipid free propofol (3 mg/kg). In all groups induction of anaesthesia was quick, smooth and uneventful. The apnea of more than 30 seconds was seen in animals of group I, which could be reduced by slow i.v. injection of propofol. The induction time was longer in animals of group I (26.16±1.52 s) than group II (19.33±0.94 s) and III (19.00±1.36 s). The duration of anaesthesia was longer in groups II (16.16±1.33 min) and III (15.33±1.44 min) than in group I (7.36±0.254 min); like wise recovery time was longer in animals of groups II (24.00±0.81 min) and III (22.16±1.69 min) than in group I (13.33±0.69 min). A good surgical anaesthesia was produced by the combination of triflupromazine HCl and lipid-free propofol, followed by diazepam and propofol and propofol, alone. Heart rate showed a significant increase, while respiration, rectal temperature and blood pressure decreased significantly following administration of lipid-free propofol up to 30 min in all groups.