The study on clinical evaluation of lipid free and lipid base propofol was conducted on 24 clinical cases of dogs of either sex. The dogs were randomly divided into 4 groups of 6 each. General anesthesia was induced by lipid free propofol intravenously in group A-I @ 4.5 mg/kg and in group A-Il @ 2.5 mg/kg and lipid base propofol in group B-I @ 4.5 mg/kg and in group B-Il @ 2.5 mg/kg. General anaesthesia was maintained with lipid free propofol @ 0.4 mg/kg/min in group A-I and A-II, and lipid base propofol @ 0.4 mg/kg/min in group B-I and B-II. In group A-II and B-II, xylazine @ 0.5 mg/kg was administered intravenously 5 min before administration of propofol. No significant alteration in rectal temperature, respiratory rate, heart rate, mean systolic and diastolic blood pressure was observed during anaesthesia and recovery. Quality of induction on anaesthesia was very good in all groups. Similarly, quality of recovery was smooth and rapid in all groups. However, prolongation of time of recovery was observed in xylazine-preanaesthetized dogs (groups A-II and B-II).
